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Optimization of a biotechnological multiproduct batch plant

A GPU parallelization of branch-and-bound for multiproduct

Jun 14, 2016 · Combinatorial optimization [] when applied in practical cases is often very time-consuming due to the "combinatorial explosion"—the number of combinations to be examined grows exponentially, such that even the fastest supercomputers would require an intolerable amount of time.A common remedy is to formulate a mixed-integer nonlinear programming (MINLP) model [6, 14] and to …

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ISSN 2693-2504 Optimization of Multiproduct Batch Plant

Basically, batch plants are composed of items operating in a discontinuous way. Each batch then visits a fixed number of equipment items, as required by a given synthesis sequence (so-called production recipe) [14]. For instance, the design of a multiproduct batch chemical plant is not only to minimize the investment cost, but also to min-

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Optimization of a biotechnological multiproduct batch

Optimization of a Biotechnological Multiproduct Batch Plant Design for the Manufacture of Four Different Products: A Real Case Scenario Gabriela Sandoval,1,2 Daniel Espinoza,3 Nicolas Figueroa,4 Juan A. Asenjo1 1Centre of Biotechnology and Bioengineering, CeBiB, Department of Chemical Engineering and Biotechnology, University of Chile, Beauchef 851, Santiago 8370456,

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Batch Process Scheduling Optimization of Multiproduct

A multiproduct batch plant which produces three acrylic fiber polymers is considered as an illustrative case study [4]. Each product undergoes the same eight processing stages and their operational and environmental considerations are fully detailed in their corresponding recipes.

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Multiobjective optimization for multiproduct batch plant

Feb 15, 2006 · The framework for batch plant design proposed in this study integrates simple unit operation models into the batch plant wide model, which is then embedded in an outer optimization loop (see Fig. 3).The approach adopted in this work consists in coupling a stochastic algorithm, indeed a genetic algorithm (GA) with a discrete-event simulator (DES) (Dietz, Azzaro-Pantel, Pibouleau, & …

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MultibioLIB: A library of biotechnological multiproduct

In our work we propose a new tool for process enginners to compare different approaches for the design of multiproduct batch plants: the performance profiles. This tool was introduced in 2002 by Dolan and Moré who claimed that "performance profiles combine the best feauters of other tools for comparing optimization solvers" and as other tools, make use of a battery of a big number -let say a

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Optimization of a biotechnological multiproduct batch

Computational results show the ability of this optimization methodology to deal with real data giving reliable solutions for a multi‐product batch plant composed of 44 unit operations in a relatively small amount of time showing that in the case studied it is possible to save up to a 66% of the capital investment in equipment given the cost data used.

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Dynamic Optimization in the Design and Scheduling of

Dynamic batch processing provides additional transient operating freedom, that can stretch the limits of profitability under strict market, facility, and time constraints. This paper incorporates dynamic processing conditions for products in a multiproduct batch plant, as opposed to fixing the process by recipes, in the broader context of equipment design, production planning, scheduling, and

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Comparison of particle swarm optimization and genetic

Jan 15, 2018 · This work deals with the problem of the optimization of multiproduct batch plant design (MBPD) found in a chemical engineering process. The aim of this work is to minimize the investment cost and find out the number and size of parallel equipment units in each stage. For this purpose, it is proposed to solve the problem in two

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Optimization of a biotechnological multiproduct batch

Computational results show the ability of this optimization methodology to deal with real data giving reliable solutions for a multiproduct batchplant composed of 44 unit operations in a relatively small amount of time showing that in the case studied it is possible to save up to a 66% of the capital investment in equipment given the cost data used

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Dynamic optimization in the design and scheduling of

Jul 01, 1996 · @article{osti_276743, title = {Dynamic optimization in the design and scheduling of multiproduct batch plants}, author = {Bhatia, T and Biegler, L T}, abstractNote = {Dynamic batch processing provides additional transient operating freedom, that can stretch the limits of profitability under strict market, facility, and time constraints. . The paper incorporates dynamic processing …

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Optimization of a biotechnological multiproduct batch

Feb 01, 2017 · Optimization of a biotechnological multiproduct batch plant design for the manufacture of four different products: A real case scenario February 2017 Biotechnology and Bioengineering 114(6)

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Optimization of a biotechnological multiproduct batch

ABSTRACT. In this work a biotechnological multiproduct batch plant that manufactures four different recombinant proteins for human application is described in some detail. This batch plant design is then optimized with regards to the size of equipment using a mixed‐integer linear programming (MILP) formulation recently developed by us in order to find a hypothetical new biotechnological batch plant …

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Continuous-Time Optimization Approach for Medium-Range

proposed optimization framework is presented. 2. Problem Description In this work, we investigate the medium-range pro-duction scheduling problem of a multiproduct batch plant, which is defined as follows: Given (i) the produc-tion recipe (i.e., the processing times for each task at the suitable units and the amount of the materials

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Design of Multiproduct Batch Plants with Units in Series

Jan 16, 2009 · This work deals with the simultaneous optimization of process decision variables and the structure of multiproduct batch plants considering the duplication of units in series to perform a given unit operation. Performance process models allow expressing the size and time factors of the posynomial formulation as a function of the process variables with the highest impact on costs. They …

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MultibioLIB: A library of biotechnological multiproduct

In our work we propose a new tool for process enginners to compare different approaches for the design of multiproduct batch plants: the performance profiles. This tool was introduced in 2002 by Dolan and Moré who claimed that "performance profiles combine the best feauters of other tools for comparing optimization solvers" and as other tools, make use of a battery of a big number -let say a

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(PDF) PRODUCT OPTIMIZATION BY SCHEDULING …

IJRET: International Journal of Research in Engineering and Technology eISSN: 2319-1163 | pISSN: 2321-7308 PRODUCT OPTIMIZATION BY SCHEDULING FORMULATION & OPTIMAL STORAGE STRATEGY FOR MULTIPRODUCT BATCH PLANTS Anand P. Dhanwani1, Srinivasarao Meka2 1 Associate Professor, Department of Chemical Engineering, Faculty of Technology, Dharmsinh Desai University, Nadiad, …

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‪Nicolas Figueroa‬ - ‪Google Scholar‬

Optimization of a biotechnological multiproduct batch plant design for the manufacture of four different products: A real case scenario G Sandoval, D Espinoza, N Figueroa, JA Asenjo Biotechnology and bioengineering 114 (6), 1252-1263, 2017

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B&B: Optimization of a biotechnological multiproduct batch

Mar 03, 2017 · Video Highlight from Juan Asenjo and Gabriela Sandoval on their recently published B&B paper entitled "Optimization of a biotechnological multiproduct batch

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Program | 4th French-Chilean Workshop on Bioprocess Modeling

Design of a real biotechnological multiproduct batch plant with an optimization based approach – abstract – slides 17:00 – 17:30 Student session Manuel Ble (Universidad de Guanajuato). Development of a Strategy for Extremum Seeking Control in a UASB-Reactor – abstract – …

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